Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is La Paz (43% of total searches to Bolivia). The next most popular destinations are Santa Cruz de la Sierra (29%) and Uyuni (14%). Searches for hotels in Tupiza (14%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Bolivia is La Paz. Santa Cruz and Pando are also very popular.