Hotels in Otay Mesa, San Diego

KAYAK searches hundreds of travel sites at once for hotels in Otay Mesa

Here is why travelers choose KAYAK

Free to useThere are no hidden charges or fees.

Filter your dealsFilter by free cancellation, free breakfast and more.

Millions of reviewsCheck ratings based on millions of real guest reviews.

Recommended by KAYAK
Useful Info
Recommended by KAYAK

Best hotels in Otay Mesa (San Diego)

Most recommended Otay Mesa hotels

Show all
Holiday Inn Express & Suites San Diego Otay Mesa - San Diego - Pool
Holiday Inn Express & Suites San Diego Otay Mesa
Otay Mesa
7.5Good(594)
Free Wi-Fi
Pool
Air Conditioning
₪628+
Check availability
Quality Suites San Diego Otay Mesa - San Diego - Bedroom
Quality Suites San Diego Otay Mesa
Otay Mesa
6.8Okay(462)
Parking
Free Wi-Fi
Pool
Air Conditioning
₪413+
Check availability
AAAmazing San Diego! Suite just for you/yours! - San Diego
AAAmazing San Diego! Suite just for you/yours!
Otay Mesa
Free Wi-Fi
Pool
Air Conditioning
₪1,130+
Check availability
Go to map

Search by stars

2+ stars3+ stars

Search by review score

6+ Okay7+ Good8+ Great9+ Excellent

Search by price

₪413 - ₪592₪592 - ₪771₪771 - ₪951₪951 - ₪1,130₪1,130+ per night

Search by freebies

Free cancellationFree breakfastFree parkingFree internet
Useful Info

KAYAK’s insights for hotels in Otay Mesa

Discover seasonal trends, ideal booking windows, and other data-driven tips to plan your stay in Otay Mesa with confidence.

Which month has the cheapest hotel rates in Otay Mesa?

Hotels are cheapest in Otay Mesa in December, with average rates of ₪1,260. In comparison, September is the most expensive month, with prices at ₪3,303.

What is the cheapest day of the week to book a hotel in Otay Mesa?

Saturday offers the lowest rates in Otay Mesa, with an average nightly price of ₪1,105. The highest prices are found on Wednesday, with average rates at ₪2,086.
Find deals

How much is a Otay Mesa hotel?

Here are our most popular & best value hotels

Top tips for finding a hotel deal in Otay Mesa

  • Not sure just how much there is to see and do in Otay Mesa? KAYAK users usually book their hotel here for 3 days.

FAQs when booking a hotel in Otay Mesa

  • What are the best hotels in Otay Mesa?

    Otay Mesa is a great part of San Diego to make your base. If you’re staying in Otay Mesa area then Quality Suites San Diego Otay Mesa, Holiday Inn Express & Suites San Diego Otay Mesa, and AAAmazing San Diego! Suite just for you/yours! are all recommended on KAYAK.

Where to stay in Otay Mesa?

Our map will help you find the perfect hotel in Otay Mesa, San Diego by showing you the exact location of each hotel.

Everything you need to know for your stay in San Diego

Otay Mesa hotel deals. Search for hotels in Otay Mesa. Find cheap hotel rooms in Otay Mesa. KAYAK searches hundreds of travel sites to help you find cheap hotels and book the room that suits you best.

Not what you’re looking for? Find thousands of other hotels, flights and car rentals with KAYAK.